Postmarketing reports: Serious cutaneous adverse reaction Rare (less than 0.1%): Erythema multiforme, pruritusįrequency not reported: Toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, bullous dermatitis, generalized mild to moderate morbilliform-like rash, acute generalized exanthematous pustulosis (AGEP), Sweet's Syndrome Pseudomembranous colitis may also be associated with toxic megacolon, which can be life-threatening.Īn unpleasant or metallic taste has occasionally been reported after high doses of IV clindamycin. The onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment and is associated with the presence of Clostridium difficile toxin in the stool.
Uncommon (0.1% to 1%): Dysgeusia, nausea, vomitingįrequency not reported: Esophageal ulcers, esophagitis (oral preparations)
GastrointestinalĬommon (1% to 10%): Pseudomembranous colitis, diarrhea, abdominal pain
#Clindamycin headache skin#
red skin lesions, often with a purple center.rash with flat lesions or small raised lesions on the skin.puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue.general feeling of tiredness or weakness.dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position.diarrhea, watery and severe, which may also be bloody.blistering, peeling, or loosening of the skin.Abdominal or stomach cramps, pain, or tenderness.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor immediately if any of the following side effects occur while taking clindamycin: Rare Serious side effects of ClindamycinĪlong with its needed effects, clindamycin may cause some unwanted effects.
Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. If CDAD is confirmed or suspected, antibiotic therapy not directed against Clostridium difficile may need to be discontinued. It is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of therapy with clindamycin.Ĭlostridium difficile associated diarrhea ( CDAD) has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild diarrhea to life-threatening colitis and has been observed to begin over 2 months after the administration of antibacterial agents. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening.
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